Due to the unique actions of Benidipine on T-type Ca+2 channels, it reduces the synthesis & release of Aldosterone from the zona glomerulosa cells of the Adrenal gland.
Calcium entering the cell through T-type channels is selectively pumped into mitochondria, while calcium entering through L-type channels would be poured into the cytosol.
This specific entry of Ca+2 via T-type channels is called the Intracellular Calcium pipeline.
Benidipine blocks the Intracellular Calcium Pipeline by blocking the T-type Ca+2 channel
Benidipine thus blocks all the cardio-renal & metabolic hazards caused by enhanced Aldosterone levels
