High T/P Ratio

The T/P ratios of Benidipine is 82% for SBP, 77% for MBP and 64% for DBP. USFDA recommends T/P ratio should be minimum 50% for an OD drugs which represents duration of action.

Arzneim.-Forsch./Drug Res. 50 (II), Nr. 7 (2000) Arzneim.-Forsch./Drug Res. 50 (II), Nr. 7 (2000)

24 Hour BP Reduction

4-mg dose of benidipine OD for 2 weeks decreases SBP/DBP by 18/10 mmHg.Another study showed a decrease in SBP/DBP by 38/16 mmHg by 4 mg Benidipine dose.

Current Therapeutic Research, vol. 53, No 3; March 1993

J-BRAVE Study

J-BRAVE showed that patients with mean age 88 years had BP reduction of 35/13 mmHg

Clinical and Experimental Hypertension, 33(5):275–280, (2011)

ABC Study

When shifted from Amlodipine to Benidipine therapy there was a further 12/9 mmHg reduction of SBP/DBP

Hypertens Res 2007; 30: 797–8

High Smoothness Index (SI)

Benidipine shows significant SIs for SBP, MBP and DBP i.e. 1.82, 1.29 and 0.76. This proves it’s consistent BP reduction over 24 Hours.

Arzneim.-Forsch./Drug Res. 50 (II), Nr. 7 (2000)

Cilnidipine to Benidipine

Benidipine resulted in a 16/5 mmHg greater reduction of SBP when shifted from Cilnidipine to Benidipine therapy

Expert Opin. Investig. Drugs (2010) 19(9):1027-1037