How does INZIT work ?

INZIT – Benidipine is a Ca⁺² channel blocker which reduce the calcium influx into vascular smooth muscle cells by interfering with voltage-operated calcium channels in the cell membrane

Benidipine is the only CCB of all the CCBs that has the triple Ca⁺² channel blocking property.

• Benidipine not only has an inhibitory effect on muscular (L type) Ca⁺² channel, but also have an inhibitory effect on N and T type Ca⁺² channels.

The unique Membrane Approach mechanism of Benidipine

• Benidipine has high affinity for cell membranes and the slow binding to and slow dissociation from the DHP binding site.

• Usual calcium channel blockers combine directly with the dihydropyridine binding site (DHP) in the cell membrane, thereby inhibiting the intracellular influx of calcium ions.
• Benidipine enters the lipid layer of the cell membrane and then diffuses extremely rapidly to the calcium channels.
• This action of Benidipine binding to the Calcium channels is called as the “Membrane approach” (approach to the cell membrane followed by long retention in the DHP binding site).

This “MEMBRANE APPROACH” of Benidipine results in its Slow binding & dissociation.