Effects on MAU by shifting from A to B
In ABC study shifting from Amlodipine to Benidipine, there was a decrease in UPE from 0.22 to 0.35 g/g Creatinine
Increases eGFR
In ABC study shifting from Amlodipine to Benidipine increases eGFR from 275 to 77 ml/min/1.73m
Diabetic Patients
In diabetic patients Benidipine decreases MAU significantly while Amlodipine increases MAU
Macroalbuminuria patients
In MAU greater than 300 mg/g patients, Benidipine decreases MAU by 25 % while Amlodipine increases MAU by 51%
CKD patients
In CKD Stage 3-5 patients, Benidipine decreases urinary protein excretion significantly as compared to Amlodipine
Decreases severe CKD risk
In mild to moderate CKD patients, Benidipine significantly decreases relative risk of developing severe CKD, while Amlodipine increases relative risk for developing severe CKD.